Our clinical genomic medicine prevention programs follow a comprehensive and structured process. The following details what you get when you enroll in one of our genomic-based disease prevention programs: Alzheimer’s Prevention, Cardiac Wellness, Diabetes Prevention, Irritable Bowel Syndrome, Macular Degeneration Prevention, or Uncommon Risk. Our corporate wellness programs are uniquely tailored to your business needs.
Personal Goal Setting
An individualized, in-depth picture of your health begins with a one-on-one consultation with Dr. Harlin where you’ll discuss your specific health concerns and set your personal goals. Dr. Harlin will also discuss the option of genetic testing including the pros and cons of testing, and the role genetic testing plays in health behavior changes.
Dr. Harlin will take a detailed medical history.
Dr. Harlin will give you a comprehensive head-to-toe physical exam and a functional fitness test, collect anthropometric data, give you a script for a biomarker assessment (blood test), and recommend a VO2 peak test if appropriate.
The Clinical Reports You’ll Receive
|Medical History Report
A detailed report of your medical history and review of medical records, organized by systems and annotated recommendations for each active problem.
|Clinical Exam Report
Findings from your physical exam, anthropometric measurements, and results of your functional fitness test performance.
Cardiorespiratory exercise prescription (ExRx) based upon American College of Sports Medicine (ACSM) guidelines. Includes needs analysis, choice of exercises, intensity guidelines, and physiologic targets based on VO2 peak results.
|Advanced Biomarkers Report
Advanced cardiovascular risk markers, measures of glucose control and metabolic syndrome risk, omega-3 and -6 fatty acids, inflammatory cytokines, micronutrient levels, and intracellular levels of metals and antioxidants.
|Three-day Food Diary Analysis
An assessment of nutritional status and needs based on your 3-day diet diary. Identifies areas of undernutrition and focuses on dietary mediators of inflammation and perturbed glucose and lipid metabolism. Serves as the springboard for individualized nutritional counseling and education with our nutritionist.
An Analysis of Over 4,000 Risk Genes and Reports Detailing How to Reduce Your Risk
To predict genetic risk, testing of single or even small numbers of susceptibility variants is of limited value. In contrast, our artificial intelligence engine clusters and calculates genetic risk scores for multiple variants, identifying those that well-designed and large-scale research studies have found to be the most influential. Taken together, gene-wide association studies (GWAS) and meta-analyses have provided unprecedented insights into disease causation and have enabled the creation of highly personalized health promotion programs. In short, our proprietary information technology matches your genetic risk markers to evidence-based interventions that help mitigate that risk.
Genetic counseling precedes the disclosure of genetic screening results and follows guidelines published by the American College of Preventive Medicine and the American College of Genetic Medicine. The discussion includes pros and cons of testing, limitations of predictive testing, and the role genetic testing plays in health behavior changes.
Polygenic Reports With Actionable Recommendations
|Genetic Susceptibility to Sixteen Common Diseases
Our genetic analysis begins with an assessment of your genetic predisposition for the following cardiometabolic and neurodegenerative diseases: myocardial infarction, hypertension and stroke, type 2 diabetes, obesity and metabolic syndrome, Alzheimer’s disease, Parkinson’s disease, hippocampal atrophy, macular degeneration, and the following cancers: bladder, breast, colorectal, esophagus, skin (melanoma), pancreas, prostate, thyroid.
|Your Top 10 Susceptibility Genes
Next, we focus on the top 10 genes found to contribute most to the disease(s) where both your genetic risk score and clinical circumstances point to an increased susceptibility.
|Inflammation, Glucose and Lipid Metabolism Genes
Genetic variants responsible for dysregulation of inflammation, glucose and lipid metabolism are evaluated. Attention is focused on the molecular mechanisms that underpin gene-environment interactions and modifiable risk factors.
Nutrigenetics refers to the role of DNA sequence variation in the responses to nutrients. This is the foundation for incorporating individuality into dietary recommendations. (Nutrigenomics refers to the study of the role of nutrients in gene expression.)
Polymorphisms in the genes that regulate circadian rhythm are associated with sleep disturbances. Here, our analysis helps recognize vulnerabilities in the circadian timing system. Combined with universal guidelines for sleep hygiene, this analysis helps us prescribe specific interventions to improve sleep homeostasis.
|Exercise Response Genes
Approximately 25% of exercise performance can be explained by genetic variation. This finding has lead to the creation of individualized training programs based on one’s genetic predispositions and susceptibility to injury. These polymorphisms are located within the genes involved in the regulation of muscle fiber type, muscle damage protection, and metabolism.
|Emotion Regulation Genes
A considerable amount of variation in stress vulnerability and emotional competency can be directly attributed to genetic factors. Our analysis flags polymorphisms shown to play an important role in threat perception and emotion regulation.
|Prosociality and Empathy Genes
Research is accumulating that suggests individual differences in temperament may be rooted in variations in genes regulating oxytocin, serotonin, and dopamine. We take a look at the best evidence supporting the genetic variants linked to idiosyncracies in prosociality and empathy.
Dr. Harlin is a certified instructor of the Benson-Henry Mind-Life Institute’s Stress Management and Resiliency Training (SMART) course and he teaches this course at New College. The SMART course is based on scientific principles and practices of mind-body medicine. Dr. Harlin will share some of the principles of this extraordinary healthcare program at our get-togethers. Our aim is to not only educate our patients about lifestyle medicine but also to strengthen patients meditation practice and interpersonal relationships. Patients are encouraged to participate in these get-togethers.